| Will Arnett | BoJack Horseman / Butterscotch Horseman (voice) |
| Aaron Paul | Todd Chavez / AA Bird / Donkey Kid / Skippy (voice) |
| Alison Brie | Diane Nguyen / Vincent Adultman / Kevin / Samantha The Food Critic / Olivia / Joelle Clark / Otter / Cow Waitress / Sarah Lynn's Assistant / Ship Co-Captain / Golden Snowflake Announcer / Nurse / Waitress / Cow Waitress / Announcer (voice) |
| Amy Sedaris | Princess Carolyn / Sharona (voice) |
| Paul F. Tompkins | Mr. Peanutbutter / Marv / Virgil Van Cleef / Prescott / Andrew Garfield / Sandro / Dog Valet / Underwater Man / Concerned Man / Janitor / Bartholomew Scagsworth / Sloth Lawyer / Blimp Co-Pilot / Abortion Doctor / George Tickle / Giant Chocolate Oscar Guy |
| Natasha Rothwell | Clemelia Bloodsworth (voice) |
| Matthew Broderick | Joseph Sugarman (voice) |
| Majandra Delfino | Henrietta Platchkey (voice) |
| David Walton | Corbin Creamerman (voice) |
| Wendie Malick | Beatrice Horseman (voice) |